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Millipore Anti-Neurofilament M Antibody Detects Level Of Neurofilament M & Has Been Published & Validated For Use In Wb & Ic. - Mill (Additional S&H or Hazmat Fees May Apply)
Chicken IgY. Liquid containing ~5 mM sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Neurofilament M Antibody detects level of Neurofilament M & has been published & validated for use in WB & IC.
Key Applications
Western Blotting
Immunocytochemistry
Application Notes
Western blot: 1:5,000-1:10,000
Immunocytochemistry: 1:1,000-1:2,000
Optimal working dilutions must be determined by the end user.
Biological Information
Immunogen
Recombinant C-terminal extension of rat NF-M, the so-called KE segment.
Host
Chicken
Specificity
Neurofilament M (NF-M)
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NM_001105541.1
NM_005382.2
Gene Symbol
NEFM
NF-M
NEF3
NFM
UniProt Number
P07197
UniProt Summary
FUNCTION: SwissProt: P07197 # Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. SIZE: 916 amino acids; 102448 Da PTM: There are a number of repeats of the tripeptide K-S-P, NFM is phosphorylated on a number of the serines in this motif. It is thought that phosphorylation of NFM results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber. & Phosphorylation seems to play a major role in the functioning of the larger neurofilament polypeptides (NF-M and NF-H), the levels of phosphorylation being altered developmentally and coincident with a change in the neurofilament function. SIMILARITY: SwissProt: P07197 ## Belongs to the intermediate filament family.
Product Usage Statements
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
