Millipore Anti-Tau (4-Repeat Isoform Rd4) Mouse Ab, 200ul

Millipore Upstate Anti-Tau (4-repeat isoform RD4) Mouse Antibody, 200 uL Net Content, Monoclonal, Mouse Host Species, Culture Supernatant, Liquid Form, -20 deg C, 1E1/A6 Clone, Bovine, Human, Mouse, Rat Species Reactivity, IgG Isotype. Microtubule associated proteins or MAPS, bind to the tubulin subunits of microtubule structures and regulate their functional stability. In the cell MAPs bind to monomer and multimerized tubulin. MAP binding to multimerized tubulin further stabilizes the formation of higher order microtubulin structures. MAP binding to microtubule structures is mediated through phosphorylation through Microtubule Affinity Regulated Kinase (MARK). Phosphorylation releases MAPs bound to microtubules, destabilizing the structure, driving it toward disassembly. There are predominately two MAP types, I, II. Type II MAP includes MAP2, MAP4 and tau and are found in nervous tissue. Six tau isoforms exist in brain tissue and they are distinguished by their number of binding domains. Three isoforms have three binding domains and the other three have four binding domains. The binding domains are located in the carboxy-terminus of the protein and are positively-charged (allowing it to bind to the negatively-charged microtubule). The isoforms with four binding domains are better at stabilizing microtubules than those with three binding domains (Additional S&H or Hazmat Fees May Apply) - Mill