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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, R | IHC, IP, WB | Rb | Purified | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | 06-676 |
| Brand Family | Upstate |
| Trade Name |
|
| Description | Anti-mGluR2/3 Antibody |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide and 30% glycerol |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-mGluR2/3 Antibody is an antibody against mGluR2/3 for use in IH, IP & WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | peptide (KQFVPTVCNGREVVDSTTSSL) corresponding to amino acids 853-872 of human metabotropic glutamate receptor 2 |
| Host | Rabbit |
| Specificity | mGluR2 and mGluR3 |
| Isotype | IgG |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. |
| Gene Symbol |
|
| Purification Method | Protein A chromatography |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. SIZE: 872 amino acids; 95568 Da SUBUNIT: Interacts with GRASP (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain. SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family. |
| Molecular Weight | 100-110kDa |
| Product Usage Statements | |
|---|---|
| Quality Assurance | routinely evaluated by immunoblot on rat brain microsomal preparation |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | 2 years at -20°C |
| Packaging Information | |
|---|---|
| Material Size | 200 µg |