Millipore Anti-Androgen Receptor Rabbit Ab, 100ul

Millipore Anti-Androgen Receptor Rabbit Antibody, 100 uL Net Content, Polyclonal, Modulation Region within the N-Terminus of Androgen Receptor Epitope, Rabbit Host Species, Affinity Purified, Liquid Form, 7.4 pH, 2 to 8 deg C, KLH Conjugate, Human, Rat Species Reactivity. Androgen receptor (UniProt: P15207, also known as Dihydrotestosterone receptor, Nuclear receptor subfamily 3 group C member 4, AR) is encoded by the Ar (also known as Nr3c4) gene (Gene ID: 24208) in rat. AR is a steroid hormone receptor that mediates the action of testosterone and dihydrotestosterone. AR is shown to be predominantly cytoplasmic in its unligated form, but translocates to the nucleus upon ligand-binding. It can also translocate to the nucleus in unligated form in the presence of RACK1. The AR contains three major functional domains - the N-terminal transcriptional regulation domain, the DNA binding domain (DBD, aa 541-614) and the ligand binding domain (aa 651-882). The DBD contains two C4-type zinc fingers (aa 542-562 and 578-602) that recognize specific DNA consensus sequences and facilitate direct DNA binding of the AR to the promoter and enhancer regions of AR-regulated genes. AR is shown to be phosphorylated in prostate cancer cells in response to several growth factors including EGF. This phosphorylation is induced by c-Src kinase. In AR, tyrosine 517 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity are associated with prostate cancer progression. Phosphorylation of AR by Tyrosine kinase non receptor 2 (TNK2) is reported to enhance the DNA-binding and transcriptional activity. AR can also be phosphorylated at serine 61 by Cdk9, which regulates its promoter selectivity and cell growth (Ref.: Davey, RA. and Grossmann, M (2016). Clin. Biochem. Rev. 37(1), 3-15) (Additional S&H or Hazmat Fees May Apply) - Mill