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Millipore Anti-Tgif2 Antibody Is A Rabbit Polyclonal Antibody For Detection Of Tgif2 Also Known As Transcription Growth Factor-Beta-Induced Factor 2 & Has Been Validated In Wb. - Mill (Additional S&H or Hazmat Fees May Apply)
TGIF2 (TGFbeta-induced transcription factor 2) is a homeobox protein that represses transcription by directly binding the DNA sequence 5-CTGTCAA-3 or by interacting with the transcriptional modulator SMAD3. TGIF2 also is thought to repress transcription via the recruitment of histone deacetylase proteins. TGIF2 is phosphorylated in response to EGF signaling by the Ras/MAPK pathway. TGIF2 is amplified and overexpressed in several ovarian cancer cell lines.
Anti-TGIF2 Antibody is a Rabbit Polyclonal Antibody for detection of TGIF2 also known as transcription growth factor-beta-induced factor 2 & has been validated in WB.
Key Applications
Western Blotting
Biological Information
Immunogen
KLH conjugated synthetic peptide (C)-EQDKEDFSSFQLLVE corresponding to a.a. 189-203 of human TGIF.
Epitope
a.a. 189-203
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Recognizes TGIF2
Species Reactivity
Human
Mouse
Rat
Antibody Type
Polyclonal Antibody
Entrez Gene Number
60436
Entrez Gene Summary
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor.
The encoded protein appears to repress transcription by recruiting histone deacetylases to TGFbeta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.
Purification Method
ImmunoAffinity Purified
UniProt Number
Q9GZN2
UniProt Summary
Transcription factor that controls the expression of the TH1 cytokine, interferon-gamma. Initiates TH1 lineage development from naive TH precursor cells both by activating TH1 genetic programs and by repressing the opposing TH2 programs.
Molecular Weight
28 kDa
Product Usage Statements
Quality Assurance
Routinely evaluated by immunoblot.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
