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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M, R | IP, WB | Rb | Serum | Polyclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | AB9906 |
| Brand Family | Chemicon® |
| Trade Name |
|
| Description | Anti-QKI-6 Antibody |
| Alternate Names |
|
| Background Information | QKI is an RNA-binding protein that plays a central role in myelinization. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. It is regulated by alternative splicing. |
| Product Information | |
|---|---|
| Format | Serum |
| Control |
|
| Presentation | Liquid. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | Anti-QKI-6 Antibody detects level of QKI-6 & has been published & validated for use in IP & WB. |
| Key Applications |
|
| Biological Information | |
|---|---|
| Immunogen | Synthetic peptide from mouse QKI-6. |
| Host | Rabbit |
| Specificity | QKI-6 (Quaking Protein). The antibody recognizes the ~38 kDa protein. |
| Species Reactivity |
|
| Antibody Type | Polyclonal Antibody |
| Entrez Gene Number |
|
| Entrez Gene Summary | QKI belongs to a family of RNA-binding proteins that have an HNRNPK (MIM 600712) homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1; MIM 602489) and SF1 (MIM 601516) (Chen and Richard, 1998 [PubMed 9671495]).[supplied by OMIM] |
| Gene Symbol |
|
| Purification Method | Serum |
| UniProt Number |
|
| UniProt Summary | FUNCTION: SwissProt: Q96PU8 # RNA-binding protein that plays a central role in myelinization. Binds to the 5-NACUAAY-N(1,20)-UAAY-3 RNA core sequence. Acts by regulating pre-mRNA splicing, mRNA export, mRNA stability and protein translation. Required to protect and promote stability of mRNAs such as MBP and CDKN1B which promotes oligodendrocyte differentiation. Participates in mRNA transport by regulating the nuclear export of MBP mRNA. Also involved in regulation of mRNA splicing of MAG pre-mRNA. Acts as a translational repressor (By similarity). SIZE: 341 amino acids; 37671 Da SUBUNIT: Homodimer. Does not require RNA to homodimerize. Able to heterodimerize with BICC1 (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). TISSUE SPECIFICITY: Expressed in the frontal cortex of brain. PTM: Methylated by PRMT1 (By similarity). & Tyrosine phosphorylated at its C-terminus, probably by FYN. Phosphorylation leads to decreased mRNA-binding affinity, affecting transport and/or stabilization of MBP mRNA (By similarity). DISEASE: SwissProt: Q96PU8 # May play a role in genetic susceptibility to schizophrenia. QKI levels of some isoforms such as isoform 6, are frequently down-regulated in schizophrenic patients. & Deletion of the QKI gene may play a role in astrocytic tumors. SIMILARITY: SwissProt: Q96PU8 ## Contains 1 KH domain. |
| Product Usage Statements | |
|---|---|
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles. |
| Packaging Information | |
|---|---|
| Material Size | 100 µL |