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Key Specifications Table
Species Reactivity | Key Applications | Host | Format | Antibody Type |
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H, Po, Fe | ELISA, WB, IH(P) | M | Purified | Monoclonal Antibody |
Description | |
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Catalogue Number | MAB335 |
Brand Family | Chemicon® |
Trade Name |
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Description | Anti-Synaptobrevin Antibody, clone SP11 |
Alternate Names |
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Product Information | |
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Format | Purified |
Presentation | Liquid in 0.02 MPB and 0.25M NaCl, PH 7.6 with 0.1% sodium azide. |
Quality Level | MQ100 |
Applications | |
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Application | This Anti-Synaptobrevin Antibody, clone SP11 is validated for use in ELISA, WB, IH(P) for the detection of Synaptobrevin. |
Key Applications |
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Application Notes | Immunohistochemistry at 1:100-1:200 Formalin fixed (fixed <4 weeks), paraffin embedded Frozen 4% Paraformaldehyde Western blotting at 1:100-1:1,000. ELISA at 1:500 Optimal working dilutions must be determined by the end user. |
Biological Information | |
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Immunogen | Crude synaptic immunoprecipitate (Human) |
Clone | SP11 |
Host | Mouse |
Specificity | Synaptobrevin [VAMP], 16kDa protein. Not reactive with bacterially expressed fusion protein. |
Isotype | IgG1 |
Species Reactivity |
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Antibody Type | Monoclonal Antibody |
Entrez Gene Number |
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Entrez Gene Summary | Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined. |
Gene Symbol |
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Non-Reactive Species |
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UniProt Number |
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UniProt Summary | FUNCTION: SwissProt: P23763 # Involved in the targeting and/or fusion of transport vesicles to their target membrane. SIZE: 118 amino acids; 12902 Da SUBUNIT: Interacts with VAPA and VAPB. SUBCELLULAR LOCATION: Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein (By similarity). & Isoform 2: Cytoplasmic vesicle membrane; Single-pass type IV membrane protein (By similarity). & Isoform 3: Mitochondrion outer membrane; Single-pass type IV membrane protein. TISSUE SPECIFICITY: Nervous system, skeletal muscle and adipose tissue. SIMILARITY: SwissProt: P23763 ## Belongs to the synaptobrevin family. & Contains 1 v-SNARE coiled-coil homology domain. |
Product Usage Statements | |
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Usage Statement |
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Storage and Shipping Information | |
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Storage Conditions | Maintain at 2-8°C in undiluted aliquots for up to 12 months. |
Packaging Information | |
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Material Size | 100 µL |