We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
Share this :
Print
Cell Signaling Gephyrin Antibody
Cell Signaling Gephyrin Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$302.00
Your Price
$302.00
HOW MUCH YOU SAVE:
0.00 %
NETA PART: | CSIG-14304S |
MFG.PART: | 14304S |
UNSPSC: | 12352200 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M R |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 93 |
Source/Isotype | Rabbit |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | Gephyrin Antibody recognizes endogenous levels of total gephyrin protein. |
Species Reactivity | Human, Mouse, Rat |
Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu517 of human gephyrin protein. Antibodies are purified by protein A and peptide affinity chromatography. |
Background | The neurotransmitters GABA and glycine activate ligand-gated chloride channels and thus mediate fast synaptic inhibition. Gephyrin is a postsynaptic, scaffolding protein anchoring type A GABA and glycine receptors to the cytoskeleton. In addition to gephyrin’s function clustering synaptic neurotransmitter receptors, it plays an essential role in the biosynthesis of the molybdenum cofactor (MoCo). Molybdenum cofactor chelates and activates sulfite oxidase, an enzyme crucial for survival (1). GSK-3β and Erk1/2 phosphorylate gephyrin at residue Ser270 and Ser268, respectively. These post-translational modifications alter the clustering of gephyrin, effecting the amplitude and frequency of GABAergic inhibitory currents (2,3). Researchers are analyzing the role of abnormal gephyrin clustering and function in major neurological, neuro-developmental and psychiatric disorders (1). |
SKU | CSIG-14304S |
---|---|
Supplier Part Number | 14304S |
UM | UNIT |
UNSPSC | 12352200 |
Manufacturer Name | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |