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Cell Signaling Ctgf (E2w5m) Rabbit mAb
Cell Signaling Ctgf (E2w5m) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
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$327.00
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NETA PART: | CSIG-10095S |
MFG.PART: | 10095S |
UNSPSC: | 12352203 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 16-20, 35 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | CTGF (E2W5M) Rabbit mAb recognizes endogenous levels of total CTGF protein. This antibody recognizes both full-length CTGF, and cleaved C-terminal fragments of CTGF, which vary in length (16-20 kDa) depending upon cleavage context. |
Species Reactivity | Human |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro265 of human CTGF protein. |
Background | Connective tissue growth factor (CTGF, CCN2) belongs to the CCN (CYR61, CTGF, NOV) family of secreted extracellular matrix (ECM) proteins (1). Members of this family contain four conserved cysteine-rich domains, and interact in the ECM with a diverse array of cell surface receptors, including integrins and heparin-sulfate proteoglycans (2). These interactions regulate a multitude of cellular and tissue functions, including adhesion, proliferation, migration, differentiation, senescence, angiogenesis, inflammation, and wound repair (1,3-5). The CTGF gene is a transcriptional target of both YAP/TAZ and TGFβ-SMAD signaling pathways (6,7), and aberrant regulation of CTGF expression is strongly associated with pathological conditions, notably cancer and fibrosis (8,9). |
SKU | CSIG-10095S |
---|---|
Supplier Part Number | 10095S |
UM | EA |
UNSPSC | 12352203 |
Manufacturer Name | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |