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Cell Signaling Sfpq Antibody
Cell Signaling Sfpq Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$302.00
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$302.00
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| NETA PART: | CSIG-23020S |
| MFG.PART: | 23020S |
| UNSPSC: | 12352203 |
| Manufacturer: | Cell Signaling |
| Size | 100 µl |
| Reactivity | H M R Mk |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 65, 75, 100 |
| Source/Isotype | Rabbit |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | SFPQ Antibody recognizes endogenous levels of total SFPQ protein. This antibody may detect a non-specific band of unknown identity at 32 kDa. |
| Species Reactivity | Human, Mouse, Rat, Monkey |
| Source/Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SFPQ protein. Antibodies are purified by peptide affinity chromatography. |
| Background | Splicing factor proline-glutamine rich (SFPQ), also commonly referred to as PTB-associated splicing factor (PSF), is an essential and ubiquitous nucleic acid-binding protein that is involved in a wide range of cellular processes. SFPQ belongs to the Drosophila melanogaster behavior, human splicing (DBHS) protein family along with paraspeckle protein 1 (PSPC1) and non-POU domain-containing octamer-binding protein (NONO) (1). DBHS proteins are a unique family of RNA-binding proteins that recruit various proteins and nucleic acids involved in transcriptional activation and repression, as well as transcript localization and splicing, and DNA damage repair (2). SFPQ and NONO are also core components of paraspeckles, which are subnuclear bodies distinct from nuclear speckles that are defined by the colocalization of SFPQ, NONO, and other proteins with the long noncoding RNA NEAT1 (2). The biological function of paraspeckles is currently unknown, but they are believed to be important for gene regulation in the presence of cellular stressors (3). Although SFPQ is typically localized to the nucleus, multiple studies indicate that cytoplasmic SFPQ levels are important for proper motor neuron differentiation and maintenance (4,5). SFPQ has also been linked to multiple neurological disorders, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS) (6-9). |
| SKU | CSIG-23020S |
|---|---|
| Supplier Part Number | 23020S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer Name | Cell Signaling |
| MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
| Temperature | -20C |
| CountryOfOrigin | US |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.00 |
| Lead Time | 5 Business Days |
| Hazardous | N |