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Tonbo Biotin Anti-Mouse Cd25 (Pc61.5)
NETA PART: | TB-30-0251-U500 |
MFG.PART: | 30-0251-U500 |
UNSPSC: | 12352203 |
Manufacturer: | Tonbo |
The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells.
The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used to distinguish Treg cells from nave or conventional T cells which are CD25-. This clone has also been reported for depletion of Treg cells in vivo (use format suitable for functional assays).
- TB (Additional S&H or Hazmat Fees May Apply)SKU | TB-30-0251-U500 |
---|---|
Supplier Part Number | 30-0251-U500 |
UM | UNIT |
UNSPSC | 12352203 |
Manufacturer Name | Tonbo |
Temperature | -20 |
Refrigerated-Frozen | Y |
CountryOfOrigin | United States |
ProductLine | TB |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |