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Cell Signaling Patl1/Pat1b (D8p1b) Rabbit mAb
Cell Signaling Patl1/Pat1b (D8p1b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
List Price
$327.00
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$327.00
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NETA PART: | CSIG-14288S |
MFG.PART: | 14288S |
UNSPSC: | 41105803 |
Manufacturer: | Cell Signaling |
Size | 100 µl |
Reactivity | H M R Mk |
Sensitivity | Endogenous |
Molecular Weight (kDa) | 95 |
Source/Isotype | Rabbit IgG |
Application/Dilution | {Western Blotting: 1:1000} |
Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
Specificity/Sensitivity | PATL1/PAT1b (D8P1B) recognizes endogenous levels of total PATL1/PAT1b protein. This antibody does not cross-react with PATL2. |
Species Reactivity | Human, Mouse, Rat, Monkey |
Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr432 of human PATL1/PAT1b protein. |
Background | PATL1/PAT1b is the human homolog of the evolutionarily conserved Pat1/Mrt1 protein, which was first identified in Saccharomyces cerevisiae (1,2). This protein is a critical component of the RNA decay machinery in the cytoplasmic processing bodies (P-bodies), localized foci of mRNA silencing and degradation (3). PATL1/PAT1b interacts with many key components of the RNA decay machinery. These include the 5’ decapping proteins DDX6/RCK, DCP1, DCP2, EDC4, and the LSm1–7 ring (3,4) as well as the 3’ deadenylation complex of CAF1-CCR4-NOT1 (3). |
SKU | CSIG-14288S |
---|---|
Supplier Part Number | 14288S |
UM | UNIT |
UNSPSC | 41105803 |
Manufacturer Name | Cell Signaling |
MSDS URL | https://www.cellsignal.com/contents/technical/safety-data-sheet-(sds)/resources-safety-data-sheets |
Temperature | -20C |
ProductLine | CSIG |
Qty | 1 |
MinOrderQty | 1 |
Weight | 7.00 |
Lead Time | 5 Business Days |